Prof. Marek Brzozowski

(24.11.1953 (DOB), MSc 1997 (Hons) in Biology, University of Lodz. PhD (Hons): 1980 University of Lodz, Institute of Chemistry. 1980-1982: PostDoc in Max-Planck-Institute fur Experimentelle Medizin, Gottingen. 1983-1989: teaching assistant in Dept of Crystallography, Univ. of Lodz. 1989-2001: Research and Senior Research Fellow, Dept. of Chemistry, Structural Biology Laboratory (YSBL), Univ. of York, UK. 2001-current: Reader, Dept. of Chemistry, YSBL, Univ. of York, UK.

Research: Structural Enzymology, Protein-RNA interactions, Structural Endocrinology (Oestrogen Receptor, IGF-I: Growth Hormone Axis, Insulin/IGF-I receptor)

Key publications: (i) Bonding of molecular oxygen to T state Human Haemoglobin. Brzozowski et al. Nature (1984), 307, 74-76, (ii) A serine protease triad forms the catalytic centre of a triacylglycerol lipase. Brady L., Nature (1990), 343, 767-770, (iii) A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex. Brzozowski et al. Nature (1991), 351, 491-497, (iv) The structure of trp RNA-binding attenuation protein. Antson et al. Nature (1995), 374, 693-700, (v) Molecular basis of agonism and antagonism in the oestrogen receptor. Brzozowski et al. Nature (1997), 389, 753-758, (vi) Structural origins of the functional divergence of human Insulin-like Growth Factor-I and Insulin. Brzozowski et al. Biochemistry (2002), 41, 9389-9397.