Centrum Doskonałości w dziedzinie Medycyny Molekularnej
   
       
     
Lecture by prof. Juan J. Calvete
   
     

Medical University of Lodz,
Department of Molecular and Medical Biophysics,
room 48,
22nd September (Thursday),
10:00

Programme:
SNAKE VENOMICS AND THE EVOLUTION OF INTEGRIN INHIBITION

Department of Molecular and Medical Biophysics Medical University of Lodz
6/8 Mazowiecka Str., 92-215 Lodz


Professor Juan J. Calvete

obtained his education at University of Valencia (from which he graduated in biochemistry in 1981) and University of Madrid (where he defended his doctoral thesis in biochemistry in 1985). Later, he held a number of postdoctoral positions: in 1986 at INSERM U63, Lyon (France), in 1987 at Banting Institute, Toronto (Canada) and, in the period of 1988 - 1989, at the Max-Planck-Institute in Munich (Germany), where he was working as Invited Scientist in the years 1989 - 1992. and, finally, in the period of 1993-1998, he was active in the position of Researcher at the Veterinary High School in Hannover, Germany. In 1989 Prof. Calvete obtained the position of the Established Investigator of the Spanish Research Council (CSIC), whereas in the period of 1993-1998 he worked as the Established Investigator of the Veterinary High School of Hannover, Germany.

At present, Prof. Calvete holds the positions of Established Investigator and Head of the Structural Proteomics Laboratory at the University of Valencia.

Among other honours, Prof. Calvete obtained the Young Scientist Award of the International Society on Thrombosis and Haemostasis in 1989 .

Scientific interests of Prof. Juan J. Calvete encompass:

-Venomics: Structural and functional proteomics of disintegrins (snake venom integrin receptor antagonists)and structural diversification of proteins by disulphide bond engineering.

-Structural biology of carbohydrate-binding proteins: spermadhesins (sperm surface-coating lectins involved in sperm physiology) and plant lectins.

-Proteomic analysis of human pathologies: Multiple myeloid leukemia, cardiovascular diseases.

-Non-conventional Proteomics: Mass spectrometric characterization of conformational features of proteins: autoimmune diseases.

Prof. Calvete is the author and co-author of numerous publications in highly-noted scientific journals: Biochemistry, Biochem.J., Thromb. Haemostas. J. Biol. Chem., Cancer Res., J. Lab. Invest., FEBS Lett., Platelets, Proteomics.