Lodz,
Rectorate of Medical University (Main Hall),
December 20th (Friday),
10:00
Programme:
THE TETRAPEPTIDE Acetyl-N-SerAspLysPro,
AN INHIBITOR OF PRIMITIVE HEMATOPOIETIC CELL PROLIFERATION,
CONTROLS NORMAL AND PATHOLOGICAL ANGIOGENESIS
Rectorate of
Medical University of Lodz
4 Kosciuszki Ave.
90-419 Lodz
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Joanna
Wdzieczak-Bakala
graduated
from University of Lodz, Poland, in 1971 (Biology) and completed
her PhD in Biochemistry at the same university in 1977. In
the year 2000 Dr Bakala obtained habilitation degree in Life
Sciences at the University of Paris XI, France .
In the period
from 1971-1973 she served as Research Assistant at
the Faculty of Medicine of Lodz (Dept. of Physiology),
whereas from 1973 to 1977 she was Research Assistant
at the University of Lodz (Dept. of Biochemistry and
Biophysics). From 1977 to 1978 Dr Bakała continued
her postdoctoral studies at the University of Lyon
1, France (Laboratory of Molecular Biology). In the
period 1978-1981 she held the position of Senior Research
Assistant at the University of Lodz (Dept. of Biochemistry
and Biophysics) and subsequently, from 1982 to 1985, she
served as Senior Research Fellow, Gustave-Roussy Institut,
Villejuif, France. At present Dr Bakala is Senior Scientist
(first class) at the National Institut of Health and Medical
Research (INSERM) and head of laboratory at the Institut
de Chimie des Substances Naturelles (ICSN) of Centre
National de la Recherche Scientifique (CNRS), Gif-sur-Yvette,
France.
Research interests of Dr Bakala comprise
regulation of hematopoiesis and angiogenesis, cancer, diabetes,
and wound-healing. Dr Bakala has published 46 articles,
100 communications, and obtained 8 patents. Her key publications
include: Inhibitor of hematopoietic pluripotent stem cell
proliferation: purification and determination of its structure. Proc
Natl Acad Sci USA, 1989, 86:779; Involvement of thymosin
b 4 and endoproteinase Asp-N in the biosynthesis of the tetrapeptide
AcSer-Asp-Lys-Pro, a regulator of the hematopoietic system. FEBS
Lett, 1990, 274:30; Involvement of human plasma angiotensin
converting enzyme in the degradation of the hemoregulatory
peptide NAc-Ser-Asp-Lys-Pro. Bioch J, 1993, 296:373;
The tetrapeptide Acetyl-Ser-Asp-Lys-Pro (Goralatide) protects
mice from doxorubicin-induced toxicity: an improvement in
both survival and hematological protection for early marrow
stem cells and progenitors. Blood, 1998, 91:441;
The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic
cell proliferation, induces angiogenesis in vitro and in
vivo. Blood, 2003, 101:3014.
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